~2012 (uncertain)
Family-reported history
Earliest symptoms
Gradual hand shaking, especially on the left side.
Read this chapterAn honest chronology · 2012–2026
My father's Parkinson's history, across countries and changing schedules. Known dates, approximate memories and gaps in the record each have their place.
A verified prescription date is not a confirmed date taken.
Each year opens and closes. Recent years start open; every earlier chapter stays one tap away.
~2012 (uncertain)
Family-reported history
Gradual hand shaking, especially on the left side.
Read this chapter2015
Family-reported history
Square Hospital, Dhaka
Diagnosed with Parkinson's disease.
Read this chapterAround Jan 2016
Family-reported history
Per family, Parkinson's medication started around Jan 2016; shaking initially stopped. Exact first medicine is unknown. This does not establish when Syndopa 125 started.
2016–2020
Incomplete record
Dhaka · Rajshahi · India
Consulted several doctors; condition progressively worsened. Family now recalls Syndopa 125 during treatment in India before ~2021, but its start date and dose frequency and other medicines remain unknown.
Read this chapterBefore ~2021 (exact date unknown)
Family-reported history
India
Father reports starting Syndopa 125 obtained during treatment in India before first consulting Prof. Dr. Md. Amirul Haque. Exact start date, tablets per dose and dose frequency are unknown; do not equate this start with Jan 2016. Syndopa 125, Codopa 275 mg and Stalevo 125 mg remain distinct reported brands/formulations.
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Around 2021
Family-reported history
Bangladesh Specialized Hospital
First consultation around 2021, after family-reported Syndopa 125 treatment in India. The medicine schedule at this consultation is not confirmed. Later documented prescriptions are dated 25 March and 21 August 2023.
Read this chapter2022
Personal context · not Parkinson's treatment
Evercare
Prostate and gallbladder-related surgery. Personal history only — not Parkinson's treatment.
25 March 2023
Verified prescription · dates taken unknown
Bangladesh Specialized Hospital · Prof. Dr. Md. Amirul Haque
Family-provided prescription documents Stalevo (carbidopa + levodopa + entacapone): one tablet morning, noon and night (1+1+1); Perkirol (ropinirole): one tablet morning and night (1+0+1). August's prescription differs. Prescription date is documented, not a confirmed date taken. Transition, overlap, duration and response are unknown. Not a current regimen.
Read this chapter21 August 2023
Verified prescription · dates taken unknown
Bangladesh Specialized Hospital · Prof. Dr. Md. Amirul Haque
Second family-provided prescription documents Codopa 275 mg (carbidopa + levodopa) and Perkirol 2 mg (ropinirole): each one tablet morning, afternoon and night (1+1+1). March listed Stalevo and twice-daily Perkirol. Codopa is not asserted to be the same brand as Syndopa. Prescription date is not a confirmed date taken; transition, overlap, duration and response are unknown. Historical only, not current.
Read this chapter2024
Family-reported history
Abu Dhabi · Dr. Shivam Om Mittal
Two tablets five times daily. Initially helpful; OFF periods persisted.
Read this chapter2024 & 2025
Personal context · not Parkinson's treatment
One eye in 2024, the other in 2025. Personal history only.
Apr–May 2025
Family-reported history
Unable to sleep, lie down comfortably, stand or walk without assistance.
Read this chapterMay–Jun 2025
Family-reported history
Bumrungrad Hospital, Bangkok · Dr. Amputch Karukote
Added to Oridopa; supervised combinations tried; ~1 month stay with physiotherapy. Sleep ~3–4 h; late-afternoon OFF remained.
Read this chapter
19 Oct 2026
Family-reported history
Oridopa ×5 doses + HBS ×3 doses (~1,300 mg levodopa/day). Many dose failures.
Read this chapter20 Oct 2026
Family-reported history
Cleveland Clinic Abu Dhabi · Dr. Shivam Om Mittal
Family-reported return visit to Dr. Mittal, who first saw my father in 2024. HBS replaced by Dispersible 125 five times daily with Oridopa (~1,500 mg levodopa/day), from ~4 PM.
Read this chapterA closer look · October 2026
My father's recorded before-and-after schedules. These are historical family records, not instructions for another patient.
Before · as of 19 October 2026
| Time | Recorded medicines |
|---|---|
| 8:00 AM | Oridopa 25/100 ×2 + Madopar HBS 125 ×1Reported relief: ~9–11 AM |
| 12:00 PM | Oridopa 25/100 ×2 + Madopar HBS 125 ×1Reported relief: ~1–3:30/4 PM |
| 4:00 PM | Oridopa 25/100 ×2Reported relief: Often ineffective |
| 8:00 PM | Oridopa 25/100 ×2Reported relief: ~9–11:30 PM |
| 11–11:30 PM | Oridopa 25/100 ×2 + Madopar HBS 125 ×1Reported relief: ~12:30–1 AM |
Occasional extra ½–1 Dispersible tablet, without fixed timing, is excluded from the scheduled total.
Scheduled levodopa: 1,300 mg/day
After · from ~4 PM, 20 October 2026
| Timing | Recorded medicines |
|---|---|
| ~4:00 PM (start, 20 Oct) | Oridopa 25/100 ×2 + Madopar Dispersible 125 ×1 |
| Every ~4 hours | Oridopa 25/100 ×2 + Madopar Dispersible 125 ×1 |
| Fifth dose | Same — exact clock time not yet verified |
Five doses daily, every ~4 hours. The exact clock time of the fifth dose is not verified.
Scheduled levodopa: 1,500 mg/day
Each Madopar 125 dose contains 100 mg levodopa + 25 mg benserazide; 125 is not the levodopa amount.
HBS was replaced by scheduled Dispersible. Oridopa continued at two tablets five times daily; Madopar moved from three recorded scheduled doses to five.
Early movement seemed better, but the first night also brought prolonged sleeplessness, recurrent unclear speech and chewing-like movements, followed by morning OFF. The reported ON interval began at noon, before the ~4 PM change. These observations do not establish cause or diagnose dyskinesia.
Read the observationsPersonal experience, not medical advice. This is one family's account. Never start, stop or change any medicine without your doctor. New or worsening slurred speech, facial drooping or sudden weakness can be an emergency — seek urgent medical help immediately. Full disclaimer