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An honest chronology · 2012–2026

Treatment Journey
One chapter at a time.

My father's Parkinson's history, across countries and changing schedules. Known dates, approximate memories and gaps in the record each have their place.

A verified prescription date is not a confirmed date taken.

Each year opens and closes. Recent years start open; every earlier chapter stays one tap away.

~2012

The first signs

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~2012 (uncertain)

Family-reported history

Earliest symptoms

Gradual hand shaking, especially on the left side.

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2015

A name for the symptoms

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2015

Family-reported history

Parkinson's diagnosis

Square Hospital, Dhaka

Diagnosed with Parkinson's disease.

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2016

Treatment begins, records remain incomplete

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Around Jan 2016

Family-reported history

Medication begins

Per family, Parkinson's medication started around Jan 2016; shaking initially stopped. Exact first medicine is unknown. This does not establish when Syndopa 125 started.

2016–2020

Incomplete record

Incomplete medication history

Dhaka · Rajshahi · India

Consulted several doctors; condition progressively worsened. Family now recalls Syndopa 125 during treatment in India before ~2021, but its start date and dose frequency and other medicines remain unknown.

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Before ~2021 (exact date unknown)

Family-reported history

Syndopa 125 — family-reported treatment in India

India

Father reports starting Syndopa 125 obtained during treatment in India before first consulting Prof. Dr. Md. Amirul Haque. Exact start date, tablets per dose and dose frequency are unknown; do not equate this start with Jan 2016. Syndopa 125, Codopa 275 mg and Stalevo 125 mg remain distinct reported brands/formulations.

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Abstract illustration of a winding path with milestone markers through teal hills, not a patient record
Some details remain in memory; missing schedules stay unknown.
2021

Care in Bangladesh

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Around 2021

Family-reported history

First consultation with Prof. Dr. Md. Amirul Haque

Bangladesh Specialized Hospital

First consultation around 2021, after family-reported Syndopa 125 treatment in India. The medicine schedule at this consultation is not confirmed. Later documented prescriptions are dated 25 March and 21 August 2023.

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2022

Personal context · not Parkinson's treatment

Unrelated surgery

Evercare

Prostate and gallbladder-related surgery. Personal history only — not Parkinson's treatment.

2023

Two documented prescriptions

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25 March 2023

Verified prescription · dates taken unknown

Stalevo 125 mg and Perkirol 2 mg — verified historical prescription

Bangladesh Specialized Hospital · Prof. Dr. Md. Amirul Haque

Family-provided prescription documents Stalevo (carbidopa + levodopa + entacapone): one tablet morning, noon and night (1+1+1); Perkirol (ropinirole): one tablet morning and night (1+0+1). August's prescription differs. Prescription date is documented, not a confirmed date taken. Transition, overlap, duration and response are unknown. Not a current regimen.

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21 August 2023

Verified prescription · dates taken unknown

Codopa 275 mg and Perkirol 2 mg — verified historical prescription

Bangladesh Specialized Hospital · Prof. Dr. Md. Amirul Haque

Second family-provided prescription documents Codopa 275 mg (carbidopa + levodopa) and Perkirol 2 mg (ropinirole): each one tablet morning, afternoon and night (1+1+1). March listed Stalevo and twice-daily Perkirol. Codopa is not asserted to be the same brand as Syndopa. Prescription date is not a confirmed date taken; transition, overlap, duration and response are unknown. Historical only, not current.

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2024

A new regimen in Abu Dhabi

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2024

Family-reported history

Oridopa 25/100

Abu Dhabi · Dr. Shivam Om Mittal

Two tablets five times daily. Initially helpful; OFF periods persisted.

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2024 & 2025

Personal context · not Parkinson's treatment

Eye laser procedures

One eye in 2024, the other in 2025. Personal history only.

2025

Difficult weeks, then Bangkok

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Apr–May 2025

Family-reported history

Most severe period

Unable to sleep, lie down comfortably, stand or walk without assistance.

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May–Jun 2025

Family-reported history

Madopar HBS 125 added

Bumrungrad Hospital, Bangkok · Dr. Amputch Karukote

Added to Oridopa; supervised combinations tried; ~1 month stay with physiotherapy. Sleep ~3–4 h; late-afternoon OFF remained.

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Anonymous illustration of physiotherapy with a caregiver, faces not shown
Physiotherapy was part of the Bangkok stay, beside the medication history.
2026

A change and close observation

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19 Oct 2026

Family-reported history

Old schedule recorded

Oridopa ×5 doses + HBS ×3 doses (~1,300 mg levodopa/day). Many dose failures.

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20 Oct 2026

Family-reported history

Switch to Madopar Dispersible

Cleveland Clinic Abu Dhabi · Dr. Shivam Om Mittal

Family-reported return visit to Dr. Mittal, who first saw my father in 2024. HBS replaced by Dispersible 125 five times daily with Oridopa (~1,500 mg levodopa/day), from ~4 PM.

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A closer look · October 2026

Same Oridopa.
A different Madopar schedule.

My father's recorded before-and-after schedules. These are historical family records, not instructions for another patient.

Before · as of 19 October 2026

Oridopa + Madopar HBS

Reported schedule before the change
TimeRecorded medicines
8:00 AMOridopa 25/100 ×2 + Madopar HBS 125 ×1Reported relief: ~9–11 AM
12:00 PMOridopa 25/100 ×2 + Madopar HBS 125 ×1Reported relief: ~1–3:30/4 PM
4:00 PMOridopa 25/100 ×2Reported relief: Often ineffective
8:00 PMOridopa 25/100 ×2Reported relief: ~9–11:30 PM
11–11:30 PMOridopa 25/100 ×2 + Madopar HBS 125 ×1Reported relief: ~12:30–1 AM

Occasional extra ½–1 Dispersible tablet, without fixed timing, is excluded from the scheduled total.

Scheduled levodopa: 1,300 mg/day

After · from ~4 PM, 20 October 2026

Oridopa + Madopar Dispersible

Reported new schedule
TimingRecorded medicines
~4:00 PM (start, 20 Oct)Oridopa 25/100 ×2 + Madopar Dispersible 125 ×1
Every ~4 hoursOridopa 25/100 ×2 + Madopar Dispersible 125 ×1
Fifth doseSame — exact clock time not yet verified

Five doses daily, every ~4 hours. The exact clock time of the fifth dose is not verified.

Scheduled levodopa: 1,500 mg/day

Each Madopar 125 dose contains 100 mg levodopa + 25 mg benserazide; 125 is not the levodopa amount.

What changed?

HBS was replaced by scheduled Dispersible. Oridopa continued at two tablets five times daily; Madopar moved from three recorded scheduled doses to five.

Early movement seemed better, but the first night also brought prolonged sleeplessness, recurrent unclear speech and chewing-like movements, followed by morning OFF. The reported ON interval began at noon, before the ~4 PM change. These observations do not establish cause or diagnose dyskinesia.

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Personal experience, not medical advice. This is one family's account. Never start, stop or change any medicine without your doctor. New or worsening slurred speech, facial drooping or sudden weakness can be an emergency — seek urgent medical help immediately. Full disclaimer