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Beyond Parkinson's

The reference library · Parkinson's medicines only

Parkinson's
Medicines

The seven medicines in my father's journey. What was prescribed, what we remember, and what remains unknown — kept distinct.

Current means the family-reported schedule as of 21 October 2026, not a recommendation or a live prescription.

A record, not a ranking.

Prescription dates do not confirm dates actually taken. Historical regimens are not current regimens.

7 medicines · all medicines

Syndopa 125 supplied packaging

Historical record

Syndopa 125

Prolonged-release tablet

Carbidopa + levodopa, prolonged release — individual ingredient strengths not verified

Family-reported treatment in India before ~2021; exact start date unknown

India · before ~2021

Schedule unknown

Exact start/stop dates, tablets per dose and frequency unknown.

Family account & source limits

My father took Syndopa CR 125 (prolonged release), which he obtained during treatment in India before first consulting Prof. Dr. Md. Amirul Haque around 2021. I do not know the dose frequency, tablets per dose, exact start and stop dates, overlap or response. His earliest Parkinson's medication began around Jan 2016, but I cannot confirm that as the Syndopa start date. I keep Syndopa 125, Codopa 275 mg and Stalevo 125 mg as distinct reported brands/formulations, not interchangeable historical records.

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Stalevo 125 mg supplied packaging

Historical record

Stalevo 125 mg

Tablet

Carbidopa + levodopa + entacapone

Documented 25 March 2023; duration unknown

25 March 2023

1 tablet · 3 times daily

Morning 1 · noon 1 · night 1. Dates taken unknown.

Family account & source limits

Verified historical family-provided prescription from Prof. Dr. Md. Amirul Haque, Bangladesh Specialized Hospital. The August prescription instead lists Codopa. Prescription dates do not confirm dates actually taken; start, stop, overlap and response are unknown. Not a current regimen.

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Codopa 275 mg supplied packaging

Historical record

Codopa 275 mg

Tablet

Carbidopa + levodopa — individual ingredient strengths not verified

Documented 21 August 2023; dates taken unknown

21 August 2023

1 tablet · 3 times daily

Morning 1 · afternoon 1 · night 1. Dates taken unknown.

Family account & source limits

Verified historical family-provided prescription from Prof. Dr. Md. Amirul Haque, Bangladesh Specialized Hospital. Listed separately from family-reported Syndopa; they are not asserted to be the same brand. Prescription date is not a confirmed date taken. Transition, overlap, duration and response are unknown. Not a current regimen.

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Perkirol 2 mg supplied packaging

Historical record

Perkirol 2 mg

Tablet

Ropinirole 2 mg

Documented 25 March and 21 August 2023; dates taken unknown

25 March 2023

1 tablet · 2 times daily

Morning 1 · noon 0 · night 1. Dates taken unknown.

21 August 2023

1 tablet · 3 times daily

Morning 1 · afternoon 1 · night 1. Dates taken unknown.

Family account & source limits

Two verified historical prescriptions from Prof. Dr. Md. Amirul Haque, Bangladesh Specialized Hospital: March lists morning/night only; August lists morning/afternoon/night. The prescription dates do not establish when either schedule was actually taken. Transition, duration and response are unknown. Not a current regimen.

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Carbidopa/Levodopa Orion 25/100 carton supplied for the Oridopa record

Current · as of 21 Oct 2026

Oridopa 25/100

Tablet

Carbidopa 25 mg + levodopa 100 mg

From 2024 (Abu Dhabi) — continuing

Family-reported · from 2024

2 tablets · 5 times daily

Continuing alongside Madopar Dispersible.

Family account & source limits

Two tablets five times daily. Initially helpful, but OFF periods persisted.

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Madopar HBS 125 supplied packaging

Historical record

Madopar HBS 125

Modified-release capsule

Levodopa 100 mg + benserazide 25 mg, modified-release

May–June 2025 (Bangkok) until 20 Oct 2026

Recorded as of 19 October 2026

1 capsule · 3 times daily

8 AM, noon and ~11–11:30 PM. Added in 2025; this exact schedule is not confirmed throughout that period.

Family account & source limits

Added to Oridopa under specialist supervision. Replaced on 20 Oct 2026.

During the Bangkok stay, sleep was around 3–4 hours and late-afternoon OFF remained. Several supervised combinations were tried; these observations cannot establish an effect of HBS alone.

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Madopar Dispersible 125 supplied packaging

Current · as of 21 Oct 2026

Madopar Dispersible 125

Dispersible tablet

Levodopa 100 mg + benserazide 25 mg

Occasional extra before 20 Oct 2026; scheduled from 20 Oct 2026

From ~4 PM, 20 October 2026

1 tablet · 5 times daily

Every ~4 hours. Exact fifth dose time unverified. Previously an occasional ½–1 tablet, without fixed timing.

Family account & source limits

Previously an occasional extra half or one tablet with no fixed timing. From ~4 PM 20 Oct 2026: one tablet every 4 hours, five times daily, per a family-reported return visit to Dr. Shivam Om Mittal at Cleveland Clinic Abu Dhabi.

Early movement seemed better, alongside prolonged sleeplessness, unclear speech and morning OFF. Cause is unconfirmed; the reported ON stretch began before the new schedule.

Read the related chapterTimeline event

The supplied Orion 25/100 carton belongs to our Oridopa 25/100 record. The Syndopa photograph is CR 125, the prolonged-release formulation my father confirmed from India. Package strength labels do not establish unverified individual ingredient strengths or historical schedules.

A closer look · October 2026

Same Oridopa.
A different Madopar schedule.

My father's recorded before-and-after schedules. These are historical family records, not instructions for another patient.

Before · as of 19 October 2026

Oridopa + Madopar HBS

Reported schedule before the change
TimeRecorded medicines
8:00 AMOridopa 25/100 ×2 + Madopar HBS 125 ×1Reported relief: ~9–11 AM
12:00 PMOridopa 25/100 ×2 + Madopar HBS 125 ×1Reported relief: ~1–3:30/4 PM
4:00 PMOridopa 25/100 ×2Reported relief: Often ineffective
8:00 PMOridopa 25/100 ×2Reported relief: ~9–11:30 PM
11–11:30 PMOridopa 25/100 ×2 + Madopar HBS 125 ×1Reported relief: ~12:30–1 AM

Occasional extra ½–1 Dispersible tablet, without fixed timing, is excluded from the scheduled total.

Scheduled levodopa: 1,300 mg/day

After · from ~4 PM, 20 October 2026

Oridopa + Madopar Dispersible

Reported new schedule
TimingRecorded medicines
~4:00 PM (start, 20 Oct)Oridopa 25/100 ×2 + Madopar Dispersible 125 ×1
Every ~4 hoursOridopa 25/100 ×2 + Madopar Dispersible 125 ×1
Fifth doseSame — exact clock time not yet verified

Five doses daily, every ~4 hours. The exact clock time of the fifth dose is not verified.

Scheduled levodopa: 1,500 mg/day

Each Madopar 125 dose contains 100 mg levodopa + 25 mg benserazide; 125 is not the levodopa amount.

What changed?

HBS was replaced by scheduled Dispersible. Oridopa continued at two tablets five times daily; Madopar moved from three recorded scheduled doses to five.

Early movement seemed better, but the first night also brought prolonged sleeplessness, recurrent unclear speech and chewing-like movements, followed by morning OFF. The reported ON interval began at noon, before the ~4 PM change. These observations do not establish cause or diagnose dyskinesia.

Read the observations

Personal experience, not medical advice. This is one family's account. Never start, stop or change any medicine without your doctor. New or worsening slurred speech, facial drooping or sudden weakness can be an emergency — seek urgent medical help immediately. Full disclaimer